Lymphocyte Proliferation Ribonucleotide Reductase and Blocks Exposure to Cigarette Tar Inhibits
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Differential inhibition of DNA synthesis in human T cells by the cigarette tar components hydroquinone and catechol.
Hydroquinone (HQ), catechol, and phenol exist in microgram quantities in cigarette tar and represent the predominant form of human exposure to benzene. Exposure of human T lymphoblasts (HTL) in vitro to 50 microM HQ or 50 microM catechol decreased IL-2-dependent DNA synthesis and cell proliferation by >90% with no effect on cell viability. Phenol had no effect on HTL proliferation at concentrat...
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